One‐Pot Preparation of Unsymmetrical Biaryls via Suzuki Cross‐Coupling Reaction of Aryl Halide using Phase‐Transfer Catalyst in a Biphasic Solvent System

Abstract

A one‐pot synthetic method of unsymmetrical biaryls was developed via the Suzuki cross‐coupling reaction of aryl halide using a phase‐transfer catalyst in a biphasic solvent system.

Keywords:

• biphasic solvent
• one‐pot reaction
• phase‐transfer catalyst
• Suzuki coupling reaction
• tetra(alkoxo)diboron
• unsymmetrical biaryls

Acknowledgments

The authors acknowledge Yuji Koga for his many helpful discussions during the preparation of this manuscript. We are also grateful to the staff of the Division of Analytical Science Laboratories of Astellas Pharma Inc. for elemental analysis and spectral measurements.