Simple and Efficient Procedure for the One‐Pot Synthesis of β‐Acetamido‐β‐aryl‐propiophenones by Molecular Iodine–Catalyzed Tandem Reaction

Abstract

Molecular iodine efficiently catalyzes the four‐component tandem reaction of araldehydes, arylmethyl ketones, acetyl chloride, and acetonitrile to afford the corresponding β‐acetamido‐β‐aryl‐propiophenones. The new protocol gives high yields of the products, and the reactions go to completion within 10–15 min on a hot plate at 80–85°C.

Keywords:

• β‐acetamido‐β‐aryl‐propiophenones
• acetonitrile, acetyl chloride
• arylaldehydes
• arylmethyl ketones
• iodine

Acknowledgments

One of the authors, Jayashankara V. P., thanks Jagadhguru Sri Sri Sri Balagangadharanatha Swamiji of Adichunchanagiri Muth, Nagamangala (Taluk), Mandya (district), Karnataka, India, for his blessings; Mrs. Faheemunnisa, assistant mistress, Government Model Higher Primary School, Aswathnagar, Bangalore, Karnataka, India, for the encouragement; and Sophisticated Instrument Facility (SIF) and Department of Organic Chemistry, Indian Institute of Science, Bangalore, for recording NMR spectra.