Practical Method for 2‐Hydroxyphenylketimine Synthesis

Abstract

A series of hydroxyphenylketimines, of which 15 are new, was synthesized in methanol at high temperature (200°C) using a sealed steel reactor. This reaction setup especially enhances the synthesis of 2‐hydroxyphenylketimines, with yields up to six times higher than those obtained with the conventional acid‐catalyzed method under refluxing conditions. In fact, some imines were achievable only by the autoclave method.

Keywords:

• autoclave
• high temperature
• imine

Acknowledgments

The financial support of the Magnus Ehrnrooth Foundation and the University of Helsinki is gratefully acknowledged. J. Matikainen's assistance in operating the mass spectrometer is greatly appreciated.