Microwave‐Assisted Synthesis of N,N′‐Disubstituted Acetamidine Ligands

Abstract

Under microwave activation, triethylorthoacetate reacts with the substituted anilines in the presence of acetic acid as a catalyst, producing acetamidine in moderate to high yields. The X‐ray structures of the new amidines, N,N′‐bis(3,5‐dimethylphenyl)‐acetamidine and N,N′‐bis(p‐tolyl)acetamidine, are also reported, revealing polymeric chains supported by intramolecular H‐bonds.

Keywords:

• amidine
• microwave‐assisted synthesis
• one pot

Acknowledgments

We thank the Thailand Research Fund (MRG4780116) for financial support. The University of Bristol is also gratefully acknowledged for CHN analysis and MS services, and Weerachai Phutdhawong is acknowledged for assistance with the microwave reactor.