Straightforward Access to Simplified Sphingosine‐1‐phosphate Analogues

Abstract

A straightforward approach for the synthesis of a new series of amino phosphates structurally related to sphingosine‐1‐phosphate is described. The commercial availability of the required starting building blocks, the reduced number of steps, and the ease of purification of the intermediate and final compounds make the approach amenable to combinatorial protocols.

Keywords:

• amino phosphate
• combinatorial
• phosphorylation
• sphingolipids

Acknowledgments

Partial financial support from Ministerio de Ciencia y Tecnología (Spain) (Project MCYT CTQ2005‐00175/BQU), Fondos Feder (EU), Fundació “La Marató de TV3” (Projects 040730 and 040731), Fundación Ramón Areces, and Generalitat de Catalunya (Project 2005SGR0163) is acknowledged.