LiBr‐Catalyzed Simple and Efficient Synthesis of Some Novel Substituted Quinolines via Friedlander Heteroannulation Reaction

Abstract

A simple and efficient method has been developed for the condensation of o‐aminoaryl ketones with α‐methylene ketones in the presence of catalytic amounts of LiBr to afford the corresponding fused cyclic quinolines in high yield using the Friedlander heteroannulation reaction. The reaction works at ambient temperature to give the products within 1.5–2 h.

Keywords:

• o‐aminoaryl ketones
• Friedlander heteroannulation
• α‐methylene ketones
• quinolines

Acknowledgment

K. A. Mahammed and V. P. Jayäshankara thank P. N. Arunachalam, senior scientific manager, Syngene Intel Ltd., India for the encouragement.