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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 2
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Original Articles

Concise and Efficient Synthesis of Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors

, , , , &
Pages 162-169 | Received 02 Jul 2007, Published online: 18 Jan 2008
 

Abstract

Highly potent and selective DPP II inhibitors N′‐(4‐Chlorobenzyl)‐N′‐methyl‐4‐oxo‐4‐(1‐piperidinyl)‐1,3‐(S)‐butane‐diamine dihydrochloride 1 and N′‐(4‐chlorobenzyl)‐4‐oxo‐4‐(1‐piperidinyl)‐1,3‐(S)‐butanediamine dihydrochloride 2 have been efficiently synthesized starting from L‐glutamine. A short and high yielding route with simple isolation techniques has been disclosed.

Acknowledgment

Authors thank Sreedhara Swamy and Ishtiyaque Ahmad for the in vitro analysis of the compounds.

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