Facile and Efficient One‐Pot Protocol for Synthesis of 5‐Phenyl‐1,4‐benzodiazepine‐2‐one Derivatives

Abstract

Several new derivatives of 5‐pheny‐1,4‐benzodiazepine‐2‐ones were synthesized from 2‐aminobenzophenone derivatives containing electron‐withdrawing substituents in one pot with mild conditions using THF as a solvent with ammonium hydroxide solution and K₂CO₃.

Keywords:

• 2‐aminobenzophenone
• 1,4‐benzodiazepine‐2‐one
• one‐pot synthesis

Acknowledgment

The authors acknowledge helpful discussion with Abdolhamid Bamoniri and financial support from Research Affairs, Kashan University, Kashan, Iran.