Abstract
Alkylation reactions of 2‐aminopyrimidine, 2‐aminothiazole, 2‐aminothiazoline, and their Cbz‐protected derivatives are described. Reactions with benzyl bromide proceed to give monoalkylated products with 2‐aminopyrimidine and 2‐aminothiazole, but 2‐aminothiazoline gives a dialkylated product. Reactions with xylylene dibromides are complicated by the tendency to form intramolecularly cyclized products with the ortho‐dibromide and insoluble products with the meta‐ and para‐dibromides.
Acknowledgments
The authors thank the Robert A. Welch Foundation (N‐1375) for support of this research.