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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 4
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Original Articles

Microwave‐Assisted Dehalogenation of α‐Haloketones by Zinc and Ammonium Chloride in Alcohol

Jian Li State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
,
Deju Ye State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
,
Hong Liu State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaCorrespondence[email protected]
,
Xiaoming Luo State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
&
Hualiang Jiang State Key Laboratory of Drug Research, Center for Drug Discovery and Design, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; School of Pharmacy, East China University of Science and Technology, Shanghai, China
Pages 567-575 | Received 17 Aug 2007, Published online: 27 Feb 2008
 
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Abstract

The treatment of α‐haloketones with 1.5 equiv. of Zn and 1 equiv. of NH4Cl in ethanol for 0.5 min gave the corresponding ketones with excellent yields under microwave irradiation. Vic‐dibromides and 2,2‐dibromoacetophenone can be efficiently debrominated to alkenes and acetophenones, respectively.

Acknowledgments

We gratefully acknowledge financial support from the State Key Program of Basic Research of China (Grant 2002CB512802, 2005BA711A01), the National Natural Science Foundation of China (Grants 30672539, 20572117, and 20472094), and the 863 Hi‐Tech Program (Grants 2006AA020402, 2006AA020602, and 2006AA020402).

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