Rapid Synthesis of 3‐Aminoimidazo[1,2‐a]Pyridines and Pyrazines

Abstract

p‐Toluenesulfonic acid catalyzed the one‐pot, three‐component synthesis of 3‐aminoimidazo[1,2‐a]pyridines and pyrazines through a condensation reaction of a 2‐aminoazine, an aldehyde, and an isocyanide at room temperature. This methodology affords a number of 3‐aminoimidazo[1,2‐a]pyridines in reasonable yields and short reaction times without any significant optimization of the reaction conditions.

Keywords:

• 3‐Aminoimidazo[1,2‐a]pyridines
• 3‐aminoimidazo[1,2‐a]pyrazines
• isocyanide
• p‐toluenesulfonic acid

Acknowledgment

We gratefully acknowledge the financial support from the Research Council of Shahid Beheshti University.