Abstract
A new strategy for the synthesis of 1,3-disubstituted uracils has been developed. The 1,3-disubstituted uracils were synthesized with good yields by amino-selenenylation of α,β-unsaturated esters and cyclization with isocyanates, followed by oxidation–elimination of the phenylseleno group.
Notes
a Isolated yields based on α,β-unsaturated ester.
a Isolated yields based on α-phenylseleno-β-amino esters 1.
a Isolated yields based on 5-phenylseleno-5,6-dihydrouracils 2.