New Strategy for the Synthesis of 1,3-Disubstituted Uracils

Abstract

A new strategy for the synthesis of 1,3-disubstituted uracils has been developed. The 1,3-disubstituted uracils were synthesized with good yields by amino-selenenylation of α,β-unsaturated esters and cyclization with isocyanates, followed by oxidation–elimination of the phenylseleno group.

Keywords:

• α-Phenylseleno-β-amino ester
• dihydrouracil
• oxidation–elimination
• uracil

Notes

^a Isolated yields based on α,β-unsaturated ester.

^a Isolated yields based on α-phenylseleno-β-amino esters 1.

^a Isolated yields based on 5-phenylseleno-5,6-dihydrouracils 2.