Abstract
4‐Substituted‐5‐methoxycarbonyl‐6‐methyl‐3,4‐dihydropyridones have been efficiently prepared on the soluble polymer polyethylene glycol (PEG) 4000 by solvent‐free microwave irradiation through a one‐pot condensation of PEG‐bound acetoacetate, Meldrum's acid, ammonium acetate, and the appropriate aldehyde in the presence of a catalytic amount of polyphosphoric acid. The polymer‐supported synthesis provided the target compounds in excellent yield and purity with a facile workup procedure.
Acknowledgment
We gratefully acknowledge financial support from the National Natural Science Foundation (NSF) of China (No. 20562005) and NSF of Jiangxi Province (No. 0620021 and No. 2007GZW0185).