New Procedure for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones by Biginelli Reaction

Abstract

A practical green chemistry procedure for synthesis of 3,4‐dihydropyrimidin‐2(1H);‐ones in good yields was successfully carried out in micellar systems according to the Biginelli reaction using β‐ketoester, urea and appropriate aromatic aldehyde in the presence of CuCl₂ · H₂O as catalyst. The advantages of this method involved the broader application scope of substrates, the more environmental friendly process and the low‐cost of the Lewis acid catalyst.

Keywords:

• Biginelli reaction
• heterocycle
• Lewis acids
• surfactant

Acknowledgments

This work was financially supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars (ROCS), State Education Ministry of China, and the startup fund of Shaanxi Normal University.