Abstract
A collection of new 1,3,5-trisubstituted piperidines has been synthesized starting from the commercially available 5-bromonicotinic acid. A unified, diastereoselective strategy allows the controlled access to both cis and trans stereochemistries. The heterocyclic compounds thus prepared bear multiple functional groups suitable for structural diversification and combichem protocols.
ACKNOWLEDGMENT
Support from Laboratorios Almirall (Barcelona, Spain), Barcelona Science Park, and DGICYT (Spain, Project BQU2006-03794) is gratefully acknowledged.