Simple Catalyst-Free Regio- and Chemoselective Monobromination of Aromatics Using NBS in Polyethylene Glycol

Abstract

NBS in polyethylene glycol has been efficiently utilized for regio- and chemoselective bromination of activated aromatics at room temperature to form the corresponding bromo products in excellent yields.

Keywords:

• Aromatic bromination
• catalyst-free
• ecofriendly reaction conditions
• PEG-400
• regio- and chemoselectivity

ACKNOWLEDGMENTS

The authors thank CSIR and UGC, New Delhi, for financial assistance.

Notes

^a The structures of the products were established from the spectral (¹H and ¹³C NMR and MS) data.

Part 125 in the series “Studies on Novel Synthetic Methodologies.”