Oxidative Bromination of Aromatic Compounds Using O-Iodoxybenzoic Acid with Tetraethylammonium Bromide

Abstract

A mild and selective procedure for the bromination of activated arenes using o-iodoxybenzoic acid and tetraethylammonium bromide is presented. The reactions were carried out at room temperature and gave moderate to excellent yields.

Keywords:

• Bromoarenes
• o-iodoxybenzoic acid
• oxidative bromination
• tetraethylammonium bromide

ACKNOWLEDGMENT

Authors thank the University Grants Commission (UGC), India, for financial support.

Notes

^a Reactions were performed on a 5 mmol scale using 1.1 equiv. of IBX with TEAB. Reactions were monitored by TLC and GC analysis on 5% OV-17 (6′, 1/8″) column and FID detector.

^b Isolated yields.