Abstract
A simple and novel bimetallic catalyst, an iron and magnesium complex (Fe‐Mg‐hexamethylphosphoramide (HMPA)), with dual activation was found to be an effective and promising catalyst for the Michael‐type Friedel–Crafts reactions of indoles with chalcones. This novel catalytic system has the advantages of highly efficient, mild reaction conditions and exhibits high reactivity and selectivity, which make it a useful and attractive process for the synthesis of indole derivatives.
Acknowledgments
This study was supported by the Natural Science Foundation of China (NSFC No. 20572114) for financial support of the work (NFSF No. 20572114) and Hangzhou Normal University.