Abstract
We have developed a highly selective synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzimidazoles from the reaction of o-phenylenediamines and aromatic aldehydes in the presence of metal hydrogen sulfates [M(HSO4)n] in water and also under solvent-free conditions in good to excellent yields.
Notes
a Isolated yields.
b Conversion.
a Isolated yield.
a Isolated yields.
b The times and yields are indicated in parentheses for reactions performed in water.