Abstract
A novel synthesis of 2-amino-5-methanesulfonylaminobenzenesulfonamide is described. This preparation begins with readily available 4-nitroaniline and proceeds through five steps (isolations) in 41% overall yield. The described chemistry is conducted on a 50- to 100-g scale and does not require extractive workup procedures or chromatographic purifications.
ACKNOWLEDGMENT
The authors thank Drs. David Kucera, Jerry (Lijian) Chen, and David Ellis for many helpful discussions during the course of this work.