New, Efficient, Selective, and One-Pot Method for Acylation of Amines

Abstract

Hydrazine hydrate with acetic and propionic acids was an efficient reagent for acylation of primary and secondary amines at reflux temperatures. The reported one-pot method is high-yielding, simple, mild, and inexpensive.

Keywords:

• Acetic acid
• acetylation
• amines
• hydrazine hydrate
• propionic acid
• propionylation

ACKNOWLEDGMENTS

The authors thank Karnatak University, Dharwad, and University Grants Commission, New Delhi, India, for financial support and thankful to the University Sophisticated Instruments Centre, Karnatak University, Dharwad, for providing the spectral data.

Notes

^a All the products were identified by comparison of their ¹H NMR, IR, mp, and bp with literature reports.^{[ 19 ]}

^b Based on recovery of the starting material, no acetylation was observed even after 24 h.

^a All the products were identified by comparison of their ¹H NMR, IR, mp, and bp with literature reports.^{[ 19 ]}

^b Based on recovery of the starting material, no propionylation was observed even after 24 h.