Abstract
An efficient and practical synthesis of dissymmetrical ethers of 4-nitrocatechol from 5-nitrosalicyladehyde and 2-hydroxy-5-nitroacetophenone via Baeyer–Villiger oxidation is described. These dissymmetrical ethers are useful in the synthesis of various coccidiostats and other important pharmaceutical intermediates.
ACKNOWLEDGMENTS
We are grateful to Shasun Research Centre (SRC) for providing the facility to do this work and for the encouragement. Our thanks are due to the SRC-QC for analytical data. We also thank M. Kathiresan for some laboratory assistance and K. Manikandan for literature assistance.
Notes
a Yields mentioned are isolated yields.