Sulfamic Acid: An Efficient, Cost-Effective, and Reusable Solid Acid Catalyst for the Synthesis of 1,8-Naphthyridines Under Solvent-Free Heating and Microwave Irradiation

Abstract

An efficient and convenient method is described for the synthesis of 1,8-naphthyridines in excellent yields by condensation of 2-aminonicotinaldehyde with various active methylene compounds in the presence of sulfamic acid as the catalyst in a solvent-free media using both conventional heating and microwave irradiation.

Keywords:

• Microwave irradiation
• 1,8-naphthyridines
• solvent-free
• sulfamic acid

Notes

^a Yields refer to pure products and all products were characterized by comparison of their physical data and ¹H NMR, ¹³C NMR, and mass spectral data with those of authentic samples.