Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 19
266
Views
11
CrossRef citations to date
0
Altmetric
Original Articles

Simple Synthesis of P1P2-Diadenosine 5′-Pyrophosphate

, , , &
Pages 3260-3269 | Received 14 Jan 2008, Published online: 12 Sep 2008
 

Abstract

Pyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5′-pyrophosphate (Ap2A) has been synthesized from adenosine-5′-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromorpholidate and adenosine monophosphate bis-(tri-n-butylammonium salt) as coupling reagents.

ACKNOWLEDGMENTS

The authors are grateful for the help and technical assistance of Andrea Armirotti. This work was supported by grants from the Italian Association for Cancer Research (AIRC), the Italian Ministry for Education, University and Scientific Research (Grants MIUR-PRIN 2003, MIUR FIRB RBNE01ERXR, and MIUR FIRB RBLA039LSF), and the Fondazione Cassa di Risparmio di Genova e Imperia.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.