Abstract
The addition of 1,2,4-triazole to Baylis–Hillman acetates mediated by Et3N was dramatically accelerated under solvent-free conditions to afford (E)-1,2,4-triazole-substituted alkenes 3 with excellent yields.
ACKNOWLEDGMENTS
We are grateful to the National Natural Science Foundation of China (Nos. 20476098 and 20676123) for financial support.
Notes
a 2.0 mmol of Baylis–Hillman acetates, 2.2 mmol of triazole, and 1.1 mmol of K2CO3 or 2.2 mmol of Et3N were used.
b Isolated yields based on Baylis–Hillman acetates.
c Complex mixture was obtained.
d The starting material was recovered.
e The ratio of 3a and 4a was determined from the 1H NMR spectrum.
a 2.0 mmol of Baylis–Hillman acetates, 2.2 mmol of triazole, and 2.2 mmol of Et3N were used.
b Isolated yields based on Baylis–Hillman acetates.
c The addition was very slow in the absence of Et3N.