Microwave-Enhanced Reactions of 4-Amino-5-merecapto-1,2,4-triazoles with Benzoyl Chloride and Aromatic Aldehydes

Abstract

The microwave-enhanced reactions of 4-amino-5-mercapto-3-substituent-1,2,4-triazoles with benzoyl chloride or arylaldehydes under solvent-free conditions without catalyst were studied. 3-Substituded-6-phenyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were easily prepared by the reactions of 4-amino-5-merecapto-3-substituded-1,2,4-triazoles with benzoyl chloride. 4-Arylideneamino-5-mercapto-3-substituted-1,2,4-triazoles were obtained by the condensation of 4-amino-5-mercapto-3-substituent-1,2,4-triazoles with arylaldehydes. This method possessed such advantages as short reaction time, environmentally benign procedures, easy purification, and high yield.

Keywords:

• 4-Arylideneamino-5-mercapto-3-substituted-4H-1
• 2
• 4-triazoles
• microwave irradiation
• solvent free
• 1
• 2
• 4-triazolo[3
• 4-b]-1
• 3
• 4-thiadiazoles
• uncatalyzed

ACKNOWLEDGMENTS

We gratefully acknowledge the Special Foundation of the Education Committee of Shaanxi Province (No. 07JK378) for support of this work.