Efficient NaOH-Catalyzed Reaction of Aromatic Aldehyde, Cyclic Ketones, and Malononitrile Under Solvent-Free Conditions Using a Grinding Method

Abstract

An efficient and facile synthesis of 2,6-dicyanoanilines via a one-pot reaction of aromatic aldehydes, malononitrile, and cyclic ketones in the presence of NaOH under solvent-free conditions using a grinding method has been developed. Compared with the classical reaction conditions, the new synthetic method has the advantages of excellent yields, shorter reaction times, and mild reaction conditions.

Keywords:

• 2,6-Dicyanoanilines
• green chemistry
• grinding
• solvent free
• synthesis

ACKNOWLEDGMENTS

We thank the PeiYu Foundation (07PYL06) of Xuzhou Normal University for financial support.

Notes

^a Reagents and conditions: 4-methylbenzaldehyde 1 (2 mmol), malononitrile 2 (5 mmol), cyclohexanone 3 (2 mmol), and NaOH (0.2 g).

^b Isolated yields.

^c Basic.

^a Reagents and conditions: 4-methylbenzaldehyde 1 (2 mmol), malononitrile 2 (5 mmol).

^b Isolated yields.