Abstract
An efficient and facile synthesis of 2,6-dicyanoanilines via a one-pot reaction of aromatic aldehydes, malononitrile, and cyclic ketones in the presence of NaOH under solvent-free conditions using a grinding method has been developed. Compared with the classical reaction conditions, the new synthetic method has the advantages of excellent yields, shorter reaction times, and mild reaction conditions.
ACKNOWLEDGMENTS
We thank the PeiYu Foundation (07PYL06) of Xuzhou Normal University for financial support.
Notes
a Reagents and conditions: 4-methylbenzaldehyde 1 (2 mmol), malononitrile 2 (5 mmol), cyclohexanone 3 (2 mmol), and NaOH (0.2 g).
b Isolated yields.
c Basic.
a Reagents and conditions: 4-methylbenzaldehyde 1 (2 mmol), malononitrile 2 (5 mmol).
b Isolated yields.