Synthesis of New 2-Aryl Substituted 2,3-Dihydroquinazoline-4(1H)-ones Under Solvent-Free Conditions, Using Molecular Iodine as a Mild and Efficient Catalyst

Abstract

A simple, inexpensive, and efficient one-pot synthesis of 2,3-dihydroquinazoline-4(1H)-one derivatives under solvent-free conditions using a catalytic amount of iodine with excellent product yields is reported. This methodology provides easy, quantitative access to various 2,3-dihydroquinazoline-4(1H)-one derivatives, using commercially available iodine as a catalyst.

Keywords:

• 2,3-Dihydroquinazolinone heterocycles
• molecular iodine
• multicomponent reactions
• solvent-free condition

ACKNOWLEDGMENT

The authors gratefully acknowledge the Research Council of K. N. Toosi University of Technology for partial financial support of this work.

Notes

^a Isolated yields.