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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 38, 2008 - Issue 21
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Original Articles

Silica-Supported Perchloric Acid (HClO4-SiO2): An Efficient Catalyst for the Preparation of β-Amido Carbonyl Compounds Using Multicomponent Reactions

, &
Pages 3766-3777 | Received 24 Apr 2008, Published online: 14 Oct 2008
 

Abstract

A new, one-pot, efficient, three-component condensation of benzaldehyde derivatives, enolizable ketones, acetyl chloride, and acetonitrile or benzonitrile in the presence of silica-supported perchloric acid as an effective catalyst for the synthesis of β-amido carbonyl compounds is described. The present methodology offers several advantages, such as good yields, short reaction times, and simple workup procedure.

ACKNOWLEDGMENTS

We are thankful to the Sistan and Baluchestan University Research Council for partial support of this work.

Notes

a Isolated products.

a Yields refer to the pure isolated products. All known products have been reported previously in the literature and were characterized by comparison of IR and NMR spectra with authentic samples.[ Citation6-26 ]

a Yields are reported after aqueous workup.

b Ratio obtained from 1H NMR of the crude reaction mixture. All syn and anti diastereomers have been reported previously in the literature, thus we compared 1H NMR spectra with authentic samples.[ Citation6-8 , Citation 23 ]

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