Diastereoselective O-Vinylation of Phenols using DMAD under Mild Reaction Conditions

Abstract

An efficient and straightforward pyridine-catalyzed method allowing selective O-vinylation of phenols with DMAD is reported. The reaction is diastereoselective and leads exclusively to (Z)-configuration in high yields.

Keywords:

• Diastereoselective
• phenol
• regioselective
• vinylation

ACKNOWLEDGMENT

We thank Gernot Boche, Philipps-Marburg University, for helpful advice with this work and Karol Gajewski for providing us access to some articles. Financial support from the University of Tehran is gratefully acknowledged.