Four-Component, One-Pot Synthesis of 2-Aryl-4-Thionylquinoline Derivatives and Their Aromatization

Abstract

Four-component, one-pot condensation of dimedon, thiophene-2-carbaldehyde, ammonium acetate, and numerous acetophenones yielded novel 2-aryl-4-thionylquinoline derivatives. The structures were characterized by ¹H NMR, ¹³C NMR, IR, and elemental analysis.

Keywords:

• Ammonium acetate
• 2-aryl-4-thionylquinoline
• dimedon
• four-component coupling reactions

ACKNOWLEDGMENT

The authors are indebted to the Department of Chemistry (Gaziosmanpasa University) and the Scientific and Technical Research Council of Turkey (Grant TUBITAK-TBAG 106T103) for financial support.

Notes

^a Yield of isolated products.