Synthesis of Ferrocenyl Schiff Bases Under Solvent-Free Conditions Using Microwave Irradiation

Abstract

Ferrocenyl imines 3a–f were synthesized using solvent-free methods by mixing ferrocene carbaldehyde 1 with amines 2a–f under microwave irradiation. The imines were obtained in good yield in short reaction times.

Keywords:

• Ferrocenyl imine
• microwave
• Schiff base
• solvent-free synthesis

ACKNOWLEDGMENTS

We gratefully acknowledge the Ministère Français des Affaires Etrangères for a grant to G. O. and support from the French embassy Bangui as well as EGIDE Paris. We thank André Loupy for encouragement and help us to do this work.

Notes

^a Yields determined by ¹H NMR (isolated yields are given in brackets).

^a Yields determined by ¹H NMR; isolated yields are given in brackets.

^b Conditions: 1 eq. amine, 120 °C, microwave, 3 min.

^c Conditions: 1 eq. amine, 120 °C, oil bath, 3 min.

^d Conditions: 2 eq. amine, 120 °C, microwave, 6 min.

^e Conditions: 2 eq. amine, 120 °C, oil bath, 6 min.

^f Conditions: 2 eq. amine, 120 °C, microwave, 30 min.

^g Conditions: 2 eq. amine, 120 °C, oil bath, 30 min.