Iodination of Aromatic Compounds Using Potassium Iodide and Hydrogen Peroxide

Abstract

A simple, efficient, regioselective, and ecofriendly method for oxyiodination of aromatic compounds is presented. In this method, the electrophilic substitutions of iodine generated in situ from KI as an iodine source and hydrogen peroxide as an oxygen source have been employed without any catalyst/mineral acid for the first time.

Keywords:

• Aromatic compounds
• iodination
• oxidant
• regioselectivity
• yield

ACKNOWLEDGMENTS

K. Suresh Kumar Reddy thanks the Council of Scientific and Industrial Research, New Delhi, for the award of a senior research Fellowship, Graduate Aptitude Test in Engineering.

Notes

^a Substrate (2 mmol), KI (2.2 mmol), 30% H₂O₂ (2.2 mmol), and acetic acid (4 ml), rt.

^b The products were characterized by ¹H NMR and mass spectra and quantified by GC.

^c 1-Iodo-2-methoxynaphthalene.