LiClO₄-Accelerated Three-Component Mannich-Type Reaction of Diethyl Malonate with Imines: An Efficient Synthesis of β-Amino Esters Under Solvent-Free Conditions

Abstract

LiClO₄ is used as catalyst for direct Mannich-type reaction of aryl aldehydes, aryl amines, and diethyl malonic ester under solvent-free conditions. This three-component reaction afforded the corresponding β-amino esters in good yields with simple and environmentally benign procedure.

Keywords:

• β-Amino esters
• diethyl malonate
• imines
• lithium perchlorate
• Mannich type
• solvent free

Notes

^a Conversion yields.

^b No reaction.

^a Conversion yields.

^b Calculated by the ¹H NMR spectrum.