Efficient Synthesis of Structurally Novel Diaryl Ethers by Regioselective Functionalization

Abstract

Synthesis of structurally novel and biologically useful 3′-substituted diaryl ethers employing Cu(0) as a catalyst, followed by regioselective either sulfonylation or carbonylation, is described.

Keywords:

• Chlorosulfonic acid
• diaryl ether
• hexamethylene tetraamine
• regioselective sulfonylation and carbonylation

Acknowledgment

We thank the management of Zydus Cadila Group for encouragement and our analytical department for support.

Notes

Note. We have used L- and D-proline as well as trans-3-hydroxy-(L)-proline as obtained from Aldrich & Co. We did not determine specific optical rotation of the final compounds though they are chiral.