Abstract
Synthesis of structurally novel and biologically useful 3′-substituted diaryl ethers employing Cu(0) as a catalyst, followed by regioselective either sulfonylation or carbonylation, is described.
Acknowledgment
We thank the management of Zydus Cadila Group for encouragement and our analytical department for support.
Notes
Note. We have used L- and D-proline as well as trans-3-hydroxy-(L)-proline as obtained from Aldrich & Co. We did not determine specific optical rotation of the final compounds though they are chiral.