Studies of 2-Substituted 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones as Precursors for the Synthesis of N-Alkyl-β-Amino Acids

Abstract

1,3-Oxazolidin-5-ones and 1,3-oxazinan-6-ones have been shown to be useful precursors for the synthesis of N-methyl α- and β-amino acids, respectively. The methodology has now been expanded to allow for the synthesis of N-alkyl-β-amino acids.

Keywords:

• β-Amino acids
• Arndt–Eistert homologation
• 1,3-oxazolidin-5-ones
• 1,3-oxazinan-6-ones

ACKNOWLEDGMENT

The authors thank La Trobe University for a post graduate scholarship provided to B.E.S.