Synthesis of Novel 1,4-Benzoxazine-2,3-Dicarboximides from Maleic Anhydride and Substituted Aromatic Amines

Abstract

A series of novel 1,4-benzoxazine-2,3-dicarboximides starting from maleic anhydride and substituted aromatic amines were synthesized.

Keywords:

• 1,4-Benzoxazine-2,3-dicarboximide
• maleic anhydride
• synthesis

ACKNOWLEDGMENTS

We are grateful to the Department of Chemistry and Pharmaceutical of Informatics Institute of Zhejiang University for ¹H NMR data, ESI-MS spectra and elemental analyses. We are also grateful to other staff of ZJU-ENS Joint Medicinal Chemistry Laboratory.

Notes

^a No data available.

^a 0.2 eq of KOH or CH₃COONa was used as catalyst.

^b Refers to temperature of oil baths.

^c Refers to isolated yield.

^d The reaction mixture turned to be dark in minutes after KOH was added to the reaction system.

^e Complex mixtures were observed on TLC, and the desired product was not isolated.