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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2008 - Issue 2
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Original Articles

Efficient Synthesis of Olmesartan Medoxomil, an Antihypertensive Drug

, , , , , , , , & show all
Pages 291-298 | Received 30 Apr 2008, Published online: 22 Dec 2008
 

Abstract

This document describes a simple and robust process for the synthesis of olmesartan medoxomil. This tailored process allows us to synthesize olmesartan medoxomil on a large scale with 50% overall yield. Also, our process has excellent control of the impurity profile in all the stages.

ACKNOWLEDGMENT

We greatly appreciate the supportive environment encouraged at Dr. Reddy's Laboratories Ltd. We are thankful to Intellectual Property Management, NMR group of Dr. Reddy's Research Foundation, and the analytical group of Integrated Product Development Organization for their generous support.

Notes

DRL-IPD Communication No. IPDO-IPM-00114

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