Antimony Trioxide as an Efficient Lewis Acid Catalyst for the Synthesis of 5-Substituted 1H-Tetrazoles

Abstract

Sb₂O₃ was found to be effective as a catalyst for a smooth (2 + 3) cycloaddition of sodium azide with nitriles to afford 5-substituted 1H-tetrazoles in good yields.

Keywords:

• Sb₂O₃
• sodium azide
• 5-substituted 1H-tetrazoles

ACKNOWLEDGMENT

The authors sincerely thank Dr. M. Lakshmi Kantham for constant encouragement and helpful discussions.

Notes

^a Reaction conditions: nitrile (1 mmol), NaN₃ (2 mmol), Sb₂O₃ (0.029 g or 0.1 mmol), DMF (5 mL), reaction time (8 h), 120 °C.

^b Isolated yields.