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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 3
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Original Articles

Efficient and Facile Three-Component Reaction for the Synthesis of 2-Amine-4,6-diarylpyrimidine Under Solvent-Free Conditions

Qiya Zhuang College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, China
,
HongXia Han College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, China
,
Suhui Wang College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, China
,
Shuajiang Tu College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, China; Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu, China
&
Liangce Rong College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, China; Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu, ChinaCorrespondence[email protected]
Pages 516-522 | Received 03 Jun 2008, Published online: 08 Jan 2009
 
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Abstract

An efficient and convenient multicomponent reaction for the preparation of 2-amine-4,6-diarylpyrimidine by aromatic aldehydes, aromatic ketones, and guanidine carbonate in the presence of sodium hydroxide under solvent-free conditions is reported. The short reaction time coupled with the simplicity of the reaction procedure make this method one of the most efficient methods for the synthesis of this class of compounds.

ACKNOWLEDGMENTS

We thank the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Pei Yu Foundation (No. 07PYL06) of Xuzhou Normal University for financial support.

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