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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 13
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Original Articles

Intramolecular 1,3-Dipolar Cycloaddition of Azomethine Ylides Leading to Pyrido[2,3-b]quinolines

Judit Tóth Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, Budapest, Hungary
,
Barbara Somfai Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, Budapest, Hungary
,
Gábor Blaskó EGIS Pharmaceuticals Ltd., Budapest, Hungary
,
András Dancsó EGIS Pharmaceuticals Ltd., Budapest, Hungary
,
László Töke Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, Budapest, Hungary
&
Miklós Nyerges Research Group of the Hungarian Academy of Sciences, Department of Organic Chemical Technology, Technical University of Budapest, Budapest, HungaryCorrespondence[email protected]
Pages 2258-2270 | Received 12 Jun 2008, Published online: 01 Jun 2009
 
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Abstract

A convenient six-step route to the previously unknown 1H-pyrrolo[2,3-f]benzo[b][1,8]naphthyridine ring system using an intramolecular 1,3-dipolar cycloaddition of nonstabilized azomethine ylides has been described.

ACKNOWLEDGMENTS

This work was financially supported by the National Fund for Science and Research, Hungary (OTKA Project No. T 046196). A grant from the EGIS Pharmaceuticals provided to J. T. is gratefully appreciated.

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