Abstract
A highly efficient protocol has been developed for the three-component reaction of an amine, an aldehyde, and diethyl phopshite catalyzed by ZrOCl2·8H2O, an environmentally friendly catalyst, at ambient temperature. The catalyst exhibited remarkable activity and tolerated a wide variety of functional groups, providing the desired amino phosphonates in excellent yields under solvent-free conditions. Alternatively, the reaction rate can be significantly enhanced by carrying out the reaction in a monomode microwave reactor as a promoter.
ACKNOWLEDGMENTS
The financial assistance from the University Grants Commission, India, for a major research project (Project No. 32–273/2006 (SR)) is acknowledged.
Notes
a Reaction conditions: aniline (1 mmol), benzaldehyde (1 mmol), diethyl phosphite (1.1 mmol), solvent (1 ml), time (8 h).
b Yields determined by GC.
a Reaction conditions: amine (1 mmol), aldehyde (1 mmol), diethyl phosphite (1.1 mmol), ZrOCl2·8H2O (0.1 mmol).
b Yields determined by GC. Yields in parantheses are of isolated compounds.