P₂O₅/SiO₂ as a New, Efficient, and Reusable Catalyst for Preparation of β-Enaminones Under Solvent-Free Conditions

Abstract

P₂O₅/SiO₂ (30% w/w) was applied as an efficient, heterogeneous, and reusable catalyst for the synthesis of β-enaminones. The reactions were rapidly completed at 80 °C under solvent-free conditions and products were obtained in good to excellent yields.

Keywords:

• Amines
• β-dicarbonyl compounds
• β-enaminone
• P₂O₅/SiO₂
• solvent-free

ACKNOWLEDGMENTS

The authors thank the Research Committee of Persian Gulf University for financial support of this work.

Notes

^a All reactions were run using dimedone (1 mmol) and aniline (1.1 mmol) in 4 mL solvent.

^b Yields referred to GC yields.

^a The structures of known enaminones 3a–r were determined by comparison of their physical properties with those of authentic samples. For new enaminones 3s–x, the structures of the products were determined from their spectroscopic (¹H and ¹³C NMR) data and CHN analysis.