Efficient One-Pot Synthesis of Polyhydroquinoline Derivatives Using Silica Sulfuric Acid as a Heterogeneous and Reusable Catalyst Under Conventional Heating and Energy-Saving Microwave Irradiation

Abstract

An efficient Hantzsch four-component condensation reaction for the synthesis of polyhydroquinoline derivatives was reported under two conditions: solvent-free conventional heating and energy-saving microwave irradiation. The process is simple and environmentally benign, and the use of a heterogeneous and reusable catalyst, high yields, and short reaction times are the key features of this protocol.

Keywords:

• Heterogeneous
• polyhydroquinoline
• silica sulfuric acid

ACKNOWLEDGMENTS

We gratefully acknowledge the financial support from the Research Council of Arak University.

Notes

^a Refluxed for 6 h.

^b 60 °C for 40 min.

^c 100 °C for 3 h.

^d Isolated yield after three consecutive runs.

^a Isolated yield.

^b Melting points are not corrected.

^a Isolated yield.

^b Melting points are not corrected.