Yttria-Zirconia–Based Lewis Acid Catalysis of the Biginelli Reaction: An Efficient One-Pot Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones

Abstract

Yttria-zirconia–based Lewis acid efficiently catalyzes the three-component cyclocondensation reaction of aldehyde, β-keto ester, and urea or thiourea in refluxing acetonitrile to produce the corresponding dihydropyrimidones in high yields.

Keywords:

• Biginelli reaction
• dihydropyrimidone
• yttria-zirconia–based Lewis acid

Notes

^a Products were characterized by spectral data and also by comparison with authentic samples.

^b Isolated yield.