Investigation of Chemoselective Reaction of 2-Amino-8-hydroxyquinoline with Arylsulfonylchloride Derivatives

Abstract

The reactions of 2-amino-8-hydroxyquinoline and 2-amino-4(1H)quinolone with different sulfonyl chlorides have been investigated. The chemoselectivity was observed to afford exclusively the arylsulfonate ester derivatives. The mechanism of the reaction is also discussed.

Keywords:

• 2-Amino-4(1H)quinolone
• 2-amino-8-hydroxyquinoline
• arylsulfonate ester
• chemoselectivity

ACKNOWLEDGMENTS

This work was supported by grants from the Brazilian agency Coordination for the Improvement of Higher Education Service (CAPES) and from DAAD (German Academic Exchange Service).