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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 9
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Original Articles

Novel Convenient Synthesis of Rivastigmine

Meng Hu Pharmacochemistry Division, Shanghai Institute of Pharmaceutical Industry, Shanghai, ChinaCorrespondence[email protected]
,
Fu-Li Zhang Pharmacochemistry Division, Shanghai Institute of Pharmaceutical Industry, Shanghai, China
&
Mei-Hua Xie Pharmacochemistry Division, Shanghai Institute of Pharmaceutical Industry, Shanghai, China
Pages 1527-1533 | Received 18 Jun 2008, Published online: 02 Apr 2009
 
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Abstract

A novel and convenient synthesis of rivastigmine has been reported. This procedure provides high yield and excellent enantiomeric excess (100% ee) starting from the diastereromerically pure (S)-1-(3-methoxyphenyl)-N-[(S)-1-phenylethyl] ethanamine.

ACKNOWLEDGMENTS

We are grateful to the Social Development Foundation of Shanghai (No. 05DZ19348) for financial support.

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