Synthesis of 6-Benzylimidazo[2,1-b][1,3]thiazole During Sonogashira Coupling

Abstract

The reaction of 2-amino-3-(2-propynyl)-1,3-thiazolium bromide 2 with various iodobenzenes 3a–f in the presence of palladium catalyst leads to the formation of 6-benzylimidazo[2,1-b][1,3]thiazoles 4a–f.

Keywords:

• Aryl iodide
• imidazothiazole
• Pd-catalyzed
• Sonogashira coupling

ACKNOWLEDGMENTS

The authors thank the Research Council of Shahrood University of Technology for the support of this work.